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Acetylsalicylic acid

InhA, Func 50-78-2

Acetylsalicylic acid (Acetylsalicylic acid)

1 image

Catalog No. ABIN3220126

Quick Overview for Acetylsalicylic acid (ABIN3220126)

Application

Inhibition Assay (InhA), Functional Studies (Func)

Purpose

Aspirin (Acetylsalicylic acid) is a potent and selective inhibitor of cyclooxygenase (COX) with a broad range of pharmacological activities including anti-inflammation and pain relief. Multiple studies have accumulated sufficient evidence to establish the association between the use of aspirin and a reduced risk of cancers including prostate cancer, breast cancer, colorectal cancer, endometrial cancer, and ovarian cancer. Aspirin suppresses ovarian cancer cells harboring COX-1 by acting as histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21. Aspirin also inhibits the expression of COX-2 in human umbilical vein endothelial cells and neonatal rat ventricular cardiomyocytes resulting in reduced PG production and the down-regulation of ERK and NF-KB respectively.

Characteristics

Tradename: ACYLPIRIN
Source of Compound: synthetic
Target: NF-κB antagonist
Receptor: NF-κB

Purification

All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.

Purity

99.50 %

Formula

C9H8O4

Solubility

Very soluble in water
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Radicicol
Inh 12772-57-5

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Application Notes

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Format

Solid

Storage

-20 °C

Storage Comment

For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.

Expiry Date

24 months
Background

Immunology/Inflammation

Molecular Weight

180.16 g/mol

CAS-No

50-78-2

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